Testosterone implants in women: Pharmacological dosing for a physiologic effect

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Testosterone implants in women: pharmacological dosing for a physiologic effect.

OBJECTIVES The objectives of this study were to determine therapeutic serum testosterone (T) levels/ranges and inter-individual variance in women treated with subcutaneous T implants. STUDY DESIGN In study group 1, T levels were measured at two separate time intervals in pre- and post-menopausal women treated with subcutaneous T for symptoms of androgen deficiency: (i) four weeks after pellet...

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Testosterone Implant Dosing Women

Serum testosterone ranges are based on endogenous hormone production. There is no evidence to support that dosing for exogenous testosterone therapy should be based on establish ranges from endogenous production (which have been shown to be inaccurate in women and children). Subcutaneous testosterone doses from 75 mg to 150 mg (and up to 225 mg) have been shown to be efficacious without signifi...

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Testosterone Hormone Therapy with Pellet Implants for Women

Hormone replacement therapy by pellet implantation has been used with great success in the United States, Europe and Australia since 1938 and found to be superior to other methods of hormone delivery (Greenblatt 49, Mishnell 41, Cantrill 84, Stanczyk 88). It is not experimental. Pellets deliver consistent, physiologic levels of hormones and avoid the fluctuations of hormone levels seen with oth...

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A radioimmunoassay for serum rat thyroglobulin. Physiologic and pharmacological studies.

A double antibody radioimmunoassay has been developed to measure thyroglobulin in rat (RTg) serum. The lowest detectable quantity measurable was 5.0 ng/ml. Specificity was documented by: (a) fall in serum RTg to undetectable levels after thyroid ablation; (b) the fact that L-thyroxine, D-thyroxine, L-triiodothyronine, D-triiodothyronine, triiodothyroacetic acid, tetraiodothyroacetic acid, triio...

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ژورنال

عنوان ژورنال: Maturitas

سال: 2013

ISSN: 0378-5122

DOI: 10.1016/j.maturitas.2012.11.004